SAFETY, TOLERABILITY, AND DOSE-LIMITING TOXICITY OF LACOSAMIDE IN PATIENTS WITH PAINFUL CHRONIC PANCREATITIS: PROTOCOL FOR A PHASE 1 CLINICAL TRIAL TO DETERMINE SAFETY AND IDENTIFY SIDE EFFECTS

BackgroundChronic abdominal pain is the hallmark symptom of chronic pancreatitis (CP), with 50% to 80% of patients seeking medical attention for pain control.Although several management options are available, outcomes are often disappointing, and opioids remain a mainstay of therapy.Opioid-induced hyperalgesia is a phenomenon resulting in dose esca

As a result of international agreements on the reduction of CO2 emissions, new technologies using hydrogen are being developed.Hydrogen, despite being the most abundant element in Nature, cannot be found in its pure state.Water is one of the most abundant sources of hydrogen on the planet.The proposal here is to use energy from the sea in order hou

BackgroundGrief is a natural and individualized response to different losses, but if grief persists or becomes pathological, professional interventions are required.Grief and corresponding interventions have received increasing attention, as the related concepts have been incorporated into the DSM-5 and ICD-11.Therefore, we conducted a bibliometric

Recent linguistic research on humour and conversation has been successfully achieved on pragmatic and sociolinguistic grounds.My contribution should try to follow this (bi)methodological trail, deepening on the study of conversation and its implications.I should call Contextual Contamination (CC) the procedure of linking together different argument

Abstract The article aims to explain road CO2 emissions, including passenger car emissions in the EU member states, with the rates of indirect taxes (except VAT) for petrol and diesel here oil.Apart from tax rates, the analysis includes some selected variables concerning economies and transport infrastructure, which impact CO2 car emissions.Compare